Research Notes

These are just some of thoughts from this weeks research. Decided to include them for your reading.

  • Importance of Sweat From recent research for this program, it has become more apparent that the absence (or reduced levels) of sweat may be an integral part of seborrheic dermatitis progression. Perhaps sweat gland malfunction requires more investigation.
  • Utilizing Acidic Solutions Using acidic (pH 3-4) solutions can help improve barrier function by stabilizing a overly alkaline skin environment [pubby id="19467032"]. However, extremely acidic solutions may cause significant irritation to damaged skin and prevent adequate barrier repair.
  • Rethinking the Spike in Seborrheic Dermatitis Occurrence at Puberty Perhaps the spike in seborrheic dermatitis seen in the beginning stages of adulthood may be partially caused by changes in hygiene practices (specifically increased washing and cleansing) which are driven by unfamiliar increases in sebum production.
  • Skin Surface pH in Infants High skin pH is also seen infants [pubby id="10878157,10633681"]. And infants are another group of individuals at higher risk of developed seborrheic dermatitis (specifically referred to as infantile seborrheic dermatitis), which resolves with age.
  • Specifics of the Nasolabial Folds (Nose Creases) Some reports have shown that sensitive skin areas such as the nasolabial folds are more resistance to external approaches to pH reduction [pubby id="9145266"].
  • Main Factors Behind Atopic Dermatitis [pubby id="23322028"]:
    • Reduced sweat secretions
    • Faulty secretion of lamellar bodies
    • Reduced free amino acids and urocanic acid
    • Filaggrin deficiencies
    • Disturbed synthesis, excretion and maturation of stratum corneum lipids
  • The Important Role of Amino Acids in Regulating Skin Surface pH The stratum corneum and the skin surface are mainly acidified by free fatty acids, amino acids, enzymatic mechanism,s and secretion of lamellar bodies [pubby doi="10.1159/000256993"], with amino acids being one of the most important.
  • Importance of pH in Skin Microbiota and Skin Disease Skin surface pH is likely the most important factor in the skin microbiota and the occurrence of common skin disease [pubby id="8665438,31403,8170842,11358544,7867722"].
  • Water in Oil Formulations Are Preferred Water in oil formulations are preferred due to their prolonged skin hydrating potential [pubby doi="10.1111/j.1610-0387.2007.06321_supp.x"].
  • Skin Surface pH is Lower in the Summer Skin surface pH value is notable lower in July then in the winter [pubby id="7389013"].
  • Lower pH Levels Have Been Noted in Seborrheic Dermatitis Some physicians have specifically noted raised skin pH levels in individuals affected by seborrheic dermatitis [pubby doi="10.1111/j.1365-2133.1958.tb13330.x"], however the data on this topic is limited.
  • Malassezia Production is Severely Inhibited at Low pH In vitro, pH 4.5 was able to inhibit malassezia growth by roughly 95% [pubby id="11146344"]